Steiner Thorsten, Weber Ralf, Krieger Derk
*Department of Neurology, University of Heidelberg, INF 400, Heidelberg 69120, Germany.
Curr Treat Options Neurol. 2001 Sep;3(5):441-450. doi: 10.1007/s11940-001-0032-7.
Increased intracerebral pressure with lethal herniation still accounts for high mortality rates in patients with massive strokes. Patients that are likely to develop increased intracranial pressure can often be identified within the first few hours after stroke onset. Although medical management seems to fail in most of these patients, early hemicraniectomy and induced moderate hypothermia (32;C to 33;C) represent two novel therapeutic approaches to improve neurologic outcomes and decrease mortality rates.
颅内压升高伴致死性脑疝仍是大面积卒中患者高死亡率的原因。在卒中发作后的最初几个小时内,通常可以识别出可能发生颅内压升高的患者。尽管在大多数此类患者中药物治疗似乎无效,但早期去骨瓣减压术和诱导性亚低温(32℃至33℃)是两种改善神经功能预后和降低死亡率的新治疗方法。