Salawu L, Olaomi O O, Paul-Odo B, Olayinka O S, Durosinmi M A
Department of Haematology, Obafemi Awolowo University, Ile-Ife, Nigeria.
Niger Postgrad Med J. 2001 Jun;8(2):90-2.
A case of duodenal perforation associated with aspirin ingestion in a 21-year old male Nigerian with sickle cell anaemia is reported. He presented with a sudden onset of epigastric pain which later spread to involve other parts of the abdomen. He had previously used aspirin at a dose of 1800 mg daily for two weeks to treat bone pain. Abdominal ultrasonography and X-ray showed fluid collection in the pelvis and elevation of the diaphragm. At exploratory laparotomy, the perforation found in the first part of the duodenum anteriorly was repaired. He was discharged 11 days post-surgery. In view of the frequent usage of salicylates and non-steroidal anti-inflammatory drugs to treat painful crises in sickle cell disease, we suggest careful monitoring of patients on such drugs and those with dyspeptic symptoms must be fully investigated including the use of endoscopy, to prevent fatal outcome.
报告了一例21岁患有镰状细胞贫血的尼日利亚男性因服用阿司匹林导致十二指肠穿孔的病例。他突发上腹部疼痛，随后疼痛蔓延至腹部其他部位。他此前曾每日服用1800毫克阿司匹林，持续两周以治疗骨痛。腹部超声和X线检查显示盆腔有积液且膈肌抬高。在剖腹探查术中，对十二指肠第一部前方发现的穿孔进行了修复。术后11天他出院了。鉴于在镰状细胞病中频繁使用水杨酸盐和非甾体类抗炎药来治疗疼痛危象，我们建议对服用此类药物的患者进行密切监测，对有消化不良症状的患者必须进行全面检查，包括使用内镜检查，以防止出现致命后果。
