Ostermann P O, Westerberg C E
Brain. 1975 Jun;98(2):189-202. doi: 10.1093/brain/98.2.189.
Twenty-two out of 235 patients with undoubted or suspected MS, treated at the Neurological Clinic, Uppsala, during the eight-year period, 1966-1973, had paroxysmal symptoms during the course of their disease. Paroxysmal dysarthria and ataxia (7 cases), and tonic seizures (5 cases) were the most common types of attacks. Some types of attacks (paroxysmal hemiataxia and crossed paraesthesiae, paroxysmal itching, diplopia as the single, paroxysmal symptom) do not seem to have been described previously. A patient with tonic seizures caused by a localized, traumatic lesion of the cervical spinal cord is also described. It is suggested that the paroxysmal phenomena in MS are caused by a transversely spreading ephaptic activation of axons within a partially demyelinated lesion in fibre tracts somewhere in the central nervous system. The different paroxysmal phenomena are discussed in the light of this hypothesis.
在1966年至1973年的八年期间，于乌普萨拉神经科诊所接受治疗的235例确诊或疑似患有多发性硬化症（MS）的患者中，有22例在病程中出现了阵发性症状。阵发性构音障碍和共济失调（7例）以及强直性发作（5例）是最常见的发作类型。某些发作类型（阵发性偏侧共济失调和交叉感觉异常、阵发性瘙痒、单独出现的复视作为阵发性症状）似乎此前未曾被描述过。本文还描述了一名由颈髓局部创伤性病变引起强直性发作的患者。有人提出，MS中的阵发性现象是由中枢神经系统某处纤维束中部分脱髓鞘病变内轴突的横向扩散性触突间兴奋所引起的。根据这一假说对不同的阵发性现象进行了讨论。
