Palmer A C, Callanan J J, Guerin L A, Sheahan B J, Stronach N, Franklin R J
Department of Clinical Veterinary Medicine, University of Cambridge.
Vet Rec. 2001 Jul 14;149(2):49-54. doi: 10.1136/vr.149.2.49.
Progressive ataxia, with head tremor, developed in 10 captive-born cheetah cubs under six months of age. The condition was usually preceded by coryza and an ocular discharge. Initially the ataxia and weakness affected the hindquarters, then the forelegs, and head tremor developed later. Significant pathological changes were confined to the central nervous system. There was widespread Wallerian degeneration in the funiculi of the spinal cord (except those in the dorsal columns), in the medulla and in the cerebellum. In the cerebellum there was degeneration of Purkinje cells and of the molecular and granular cell layers. There was chromatolysis in the Purkinje cells, the ventral horn cells of the spinal cord and in the neurons of the lateral vestibular nucleus. The olivary nucleus was necrotic. There were foci of inflammatory cells in the molecular layer of the cerebellum and in the medulla. The cause of the disease remains unknown.
10只圈养出生、6个月龄以下的猎豹幼崽出现了进行性共济失调，并伴有头部震颤。这种情况通常先出现鼻炎和眼部分泌物。最初，共济失调和虚弱影响后肢，然后是前肢，头部震颤随后出现。显著的病理变化局限于中枢神经系统。脊髓白质（除后索外）、延髓和小脑中存在广泛的华勒氏变性。小脑中浦肯野细胞、分子层和颗粒细胞层发生变性。浦肯野细胞、脊髓前角细胞和外侧前庭核神经元出现染色质溶解。橄榄核坏死。小脑分子层和延髓中有炎症细胞灶。病因仍不明。
