Mayhew I G, deLahunta A, Whitlock R H, Geary J C
J Am Vet Med Assoc. 1977 Jan 15;170(2):195-201.
Five horses of mixed breeding and 1 zebra with symmetric tetraparesis and ataxia were studied. There were 2 females and 4 males. Signs of illness were first noticed from birth to 12 months of age. Clinical and pathologic studies were performed when the animals were 4 to 24 months old. Two of the horses were related. All of the subjects had diffuse degenerative myeloencephalopathy. The degeneration was most pronounced in thoracic segments of the spinal cord. Ventral and dorsolateral funiculi were most severely affected. Axonal swelling and abnormal neuronal cell bodies were seen in the gray matter of the spinal cord and in some brain-stem nuclei. These changes were most prominent in the nuclei of the dorsal spinocerebellar tract. The cause was not determined.
对5匹杂交马和1匹患有对称性四肢轻瘫和共济失调的斑马进行了研究。其中有2匹雌性和4匹雄性。疾病迹象最早在出生至12个月大时被发现。当这些动物4至24个月大时进行了临床和病理研究。其中2匹马有亲缘关系。所有受试动物均患有弥漫性退行性脊髓脑病变。脊髓胸段的退变最为明显。腹侧和背外侧索受影响最严重。在脊髓灰质和一些脑干核中可见轴突肿胀和异常神经元细胞体。这些变化在背侧脊髓小脑束核中最为突出。病因尚未确定。
