Sutoo D, Akiyama K
Institute of Medical Science, University of Tsukuba, Japan.
Jpn J Pharmacol. 2001 Jul;86(3):366-8. doi: 10.1254/jjp.86.366.
The effects of intracerebroventricular administration of calcium or magnesium on the blood pressure regulation in the brain were investigated. The systolic blood pressure in spontaneously hypertensive rats (male, 13-week-old) was decreased by calcium chloride (100 microg/rat) and increased by magnesium chloride (20, 100 or 500 microg/rat). The depressor response induced by calcium was inhibited by magnesium chloride in a dose-dependent manner. Combining these results with those previously reported, it is suggested that magnesium inhibits the ability of calcium to reduce blood pressure through calmodulin- and dopamine-dependent functions in the brain.
研究了脑室内注射钙或镁对脑内血压调节的影响。氯化钙（100微克/只）可降低自发性高血压大鼠（雄性，13周龄）的收缩压，而氯化镁（20、100或500微克/只）则可使其升高。氯化钙诱导的降压反应被氯化镁以剂量依赖的方式抑制。将这些结果与先前报道的结果相结合，表明镁通过大脑中钙调蛋白和多巴胺依赖的功能抑制钙降低血压的能力。
