Summanen J O, Vuorela H J, Hiltunen R K
Department of Pharmacy, University of Helsinki, Finland.
J Pharm Sci. 1994 Feb;83(2):249-51. doi: 10.1002/jps.2600830227.
The effects of an orally administered potassium and magnesium supplementation on the systolic blood pressure of 42 spontaneously hypertensive rats were determined for 10 weeks. The experimental preparation was mixed with standard rat pellets and this mixture was given to three rat groups at three concentrations: 6%, 9%, and 12%. Potassium- and magnesium-containing nutrient statistically significantly inhibited the normal increase in systolic blood pressure in these rats. It could even decrease the systolic blood pressure below the initial level and its effect was similar to the known calcium antagonist verapamil. The systolic blood pressure of rats fed with the standard pellet diet containing 6% sodium chloride (NaCl) increased from 191 to 209 mmHg, whereas that of animals on 6% K-Mg supplementation decreased from 197 to 181 mmHg. 9% and 12% K-Mg supplementation produced an almost equally significant decrease in systolic blood pressure, according to Student's unpaired t-test. The experimental nutrient could possibly be used in human studies on the feasibility of normalizing blood pressure by reducing the harmful effects of dietary salt.
研究口服补充钾和镁对42只自发性高血压大鼠收缩压的影响，为期10周。将实验制剂与标准大鼠颗粒饲料混合，以三种浓度（6%、9%和12%）给予三组大鼠。含钾和镁的营养素在统计学上显著抑制了这些大鼠收缩压的正常升高。它甚至可以使收缩压降至初始水平以下，其效果与已知的钙拮抗剂维拉帕米相似。喂食含6%氯化钠（NaCl）标准颗粒饲料的大鼠收缩压从191 mmHg升至209 mmHg，而补充6%钾 - 镁的动物收缩压从197 mmHg降至181 mmHg。根据学生非配对t检验，补充9%和12%钾 - 镁使收缩压下降的幅度几乎同样显著。这种实验性营养素可能可用于人体研究，以探讨通过减少膳食盐的有害影响来使血压正常化的可行性。
