一种新的氧化四氢原小檗碱生物碱及延胡索的抗血小板聚集成分。

A new tetrahydroprotoberberine N-oxide alkaloid and anti-platelet aggregation constituents of Corydalis tashiroi.

作者信息

Chen J J, Chang Y L, Teng C M, Lin W Y, Chen Y C, Chen I S

机构信息

Department of Pharmacy, Tajen Institute of Technology, Pingtung, Taiwan, Republic of China.

出版信息

Planta Med. 2001 Jul;67(5):423-7. doi: 10.1055/s-2001-15820.

DOI:10.1055/s-2001-15820

PMID:11488455

Abstract

A new tetrahydroprotoberberine N-oxide alkaloid, (-)-cis-isocorypalmine N-oxide (1), together with two known compounds, 6-methoxydihydrosanguinarine (2) and norjuziphine (3), were isolated in continuing studies of the entire Formosan Corydalis tashiroi plant. The structures of these three compounds were determined through spectral analyses. In addition, compounds 1, 2, 3 and the seven alkaloids previously reported: (-)-cis-corydalmine N-oxide, (-)-trans-corydalmine N-oxide, (-)-trans-isocorypalmine N-oxide, scoulerine, protopine, oxysanguinarine and corydalmine, were found to possess antiplatelet aggregation activity.

摘要

在对台湾延胡索整株植物的持续研究中，分离出了一种新的四氢原小檗碱氮氧化物生物碱，(-)-顺式异紫堇杷明氮氧化物(1)，以及两种已知化合物，6-甲氧基二氢血根碱(2)和去氢紫堇碱(3)。通过光谱分析确定了这三种化合物的结构。此外，还发现化合物1、2、3以及先前报道的七种生物碱：(-)-顺式紫堇达明氮氧化物、(-)-反式紫堇达明氮氧化物、(-)-反式异紫堇杷明氮氧化物、紫堇灵、原阿片碱、氧化血根碱和紫堇达明，具有抗血小板聚集活性。