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来自[植物名称]茎的抗氧化、抗α-葡萄糖苷酶、抗酪氨酸酶和抗乙酰胆碱酯酶成分及分子对接研究

Antioxidant, Anti-α-Glucosidase, Anti-Tyrosinase, and Anti-Acetylcholinesterase Components from Stem of with Molecular Docking Study.

作者信息

Tsai Chia-Hsuan, Liou Ya-Lun, Li Sin-Min, Liao Hsiang-Ruei, Chen Jih-Jung

机构信息

Department of Plastic and Reconstructive Surgery, Keelung Chang Gung Memorial Hospital, Keelung 204201, Taiwan.

College of Medicine, Chang Gung University, Taoyuan 333323, Taiwan.

出版信息

Antioxidants (Basel). 2024 Dec 24;14(1):8. doi: 10.3390/antiox14010008.

DOI:10.3390/antiox14010008
PMID:39857342
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11761247/
Abstract

is a creeping evergreen shrub endemic to Taiwan. In traditional medicine, Rhamnaceae plants are used as herbal remedies for conditions such as itching, difficulty urinating, and constipation. This study explores the inhibitory effects of various solvent extracts and bioactive components of on α-glucosidase, tyrosinase, acetylcholinesterase (AChE), and antioxidant activity. The 100 °C water extract exhibited strong antioxidant activity in DPPH, ABTS, superoxide, and FRAP assays. The methanol extract demonstrated the highest α-glucosidase inhibitory effect, while the ethanol extract displayed potent AChE inhibition and the acetone extract showed the most potential tyrosinase inhibitory activity among the extracts. Five main biocomponents were isolated and evaluated for their bioactivities. Among them, kaempferol () and quercetin () exhibited notable antioxidant activity in DPPH and ABTS assays. Particularly, kaempferol () performed the best -glucosidase inhibitory effect, physcion () showed the strongest AChE inhibition, and quercetin () demonstrated the most potential for tyrosinase inhibitory activity. Further molecular docking studies revealed that there may be stronger binding mechanisms between bioactive components and target enzymes (including α-glucosidase, acetylcholinesterase, and tyrosinase) than the positive control. These findings suggest that bioactive extracts and compounds from the stems of may have potential as natural antioxidant, anti-α-glucosidase, anti-AChE, and anti-tyrosinase drug candidates or dietary supplements for the management of oxidative stress-related conditions, including hyperglycemia, pigmentation disorders, and neurodegenerative diseases.

摘要

是一种台湾特有的匍匐常绿灌木。在传统医学中，鼠李科植物被用作草药治疗瘙痒、排尿困难和便秘等病症。本研究探讨了[植物名称]的各种溶剂提取物和生物活性成分对α-葡萄糖苷酶、酪氨酸酶、乙酰胆碱酯酶（AChE）的抑制作用以及抗氧化活性。100℃水提取物在DPPH、ABTS、超氧化物和FRAP测定中表现出较强的抗氧化活性。甲醇提取物表现出最高的α-葡萄糖苷酶抑制作用，而乙醇提取物显示出较强的AChE抑制作用，丙酮提取物在提取物中表现出最强的酪氨酸酶抑制活性。分离出五种主要生物成分并评估其生物活性。其中，山柰酚（）和槲皮素（）在DPPH和ABTS测定中表现出显著的抗氧化活性。特别是，山柰酚（）对α-葡萄糖苷酶的抑制作用最佳，大黄素（）对AChE的抑制作用最强，槲皮素（）对酪氨酸酶的抑制活性潜力最大。进一步的分子对接研究表明，生物活性成分与靶酶（包括α-葡萄糖苷酶、乙酰胆碱酯酶和酪氨酸酶）之间可能存在比阳性对照更强的结合机制。这些发现表明，[植物名称]茎中的生物活性提取物和化合物可能具有作为天然抗氧化剂、抗α-葡萄糖苷酶、抗AChE和抗酪氨酸酶药物候选物或膳食补充剂的潜力，用于管理与氧化应激相关的病症，包括高血糖、色素沉着紊乱和神经退行性疾病。

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