来自秀丽香树的阿朴啡和菲啶生物碱对血小板活化因子受体结合的抑制作用。
Inhibition of platelet-activating factor receptor binding by aporphine and phenanthrenoid alkaloids from Aromadendron elegans.
作者信息
Jantan I, Rafi I A, Jalil J
机构信息
receptor binding, with IC50 values of 52.4, 38.6, and 29.8 microM, respectively. The flexibility of the biphenyl system of the aporphine and the presence of methoxy groups at C-9 and C-10 were all preferable in binding to the receptor.
出版信息
Planta Med. 2001 Jul;67(5):466-7. doi: 10.1055/s-2001-15819.
Six aporphine and one phenanthrenoid alkaloids isolated from Aromadendron elegans Blume were investigated for their inhibitory effect on platelet-activating factor (PAF) binding to rabbit platelets using 3H-PAF as a ligand. Of the compounds tested, (-)-N-acetylanonaine, 1-(N-acetyl-N-methylamino)ethyl-3,4,6-trimethoxy-7-hydroxy-phenanthrene, and predicentrine showed strong inhibition of
对从秀丽香树（Aromadendron elegans Blume）中分离出的六种阿朴啡碱和一种菲类生物碱进行了研究，以3H-PAF作为配体，考察它们对血小板活化因子（PAF）与兔血小板结合的抑制作用。在所测试的化合物中，（-）-N-乙酰去甲乌药碱、1-（N-乙酰-N-甲氨基）乙基-3,4,6-三甲氧基-7-羟基菲和前胡素表现出强烈的抑制作用。
Zotero 插件