从侧柏中分离和鉴定血小板活化因子受体结合拮抗剂。
Isolation and characterization of platelet-activating factor receptor binding antagonists from Biota orientalis.
作者信息
Yang H O, Suh D Y, Han B H
机构信息
Natural Products Research Institute, Seoul National University, Republic of Korea.
出版信息
Planta Med. 1995 Feb;61(1):37-40. doi: 10.1055/s-2006-957995.
The leaf extract of Biota orientalis showed potent PAF receptor binding antagonistic activity in our previous screening studies on 234 Korean medicinal plants using rabbit platelet receptor binding tests. The activity-guided purification of the plant extract resulted in the isolation of six compounds, including two active substances. The chemical structures of the compounds isolated were established by chemical and spectrometric analyses as dotriacontane, totarol, 8 beta-hydroxy-3-oxopimar-15-ene, cedrol (IC50 = 1.3 x 10(-5) M), pinusolide (IC50 = 2.52 x 10(-7) M), and 5-hydroxy-7,4'-dimethoxyflavone.
在我们之前使用兔血小板受体结合试验对234种韩国药用植物进行的筛选研究中，侧柏叶提取物显示出强大的血小板活化因子（PAF）受体结合拮抗活性。对该植物提取物进行活性导向纯化，得到了六种化合物，其中包括两种活性物质。通过化学和光谱分析确定，分离得到的化合物的化学结构分别为三十二烷、脱氢松香酚、8β-羟基-3-氧代海松-15-烯、雪松醇（IC50 = 1.3×10⁻⁵ M）、松脂素（IC50 = 2.52×10⁻⁷ M）和5-羟基-7,4'-二甲氧基黄酮。
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