Zachariae R, Jørgensen M M, Egekvist H, Bjerring P
Psycho-oncology Research Unit, Aarhus University Hospital, Barthsgade 5,3 DK8200 Aarhus N, Denmark.
Allergy. 2001 Aug;56(8):734-40. doi: 10.1034/j.1398-9995.2001.056008734.x.
The severity of symptoms in asthma and other hypersensitivity-related disorders has been associated with changes in mood but little is known about the mechanisms possibly mediating such a relationship. The purpose of this study was to examine the influence of mood on skin reactivity to histamine by comparing the effects of hypnotically induced emotions on flare and wheal reactions to cutaneous histamine prick tests.
Fifteen highly hypnotically susceptible volunteers had their cutaneous reactivity to histamine measured before hypnosis at 1, 2, 3, 4, 5, 10, and 15 min after the histamine prick. These measurements were repeated under three hypnotically induced emotions of sadness, anger, and happiness presented in a counterbalanced order. Skin reactions were measured as change in histamine flare and wheal area in mm2 per minute.
The increase in flare reaction in the time interval from 1 to 3 min during happiness and anger was significantly smaller than flare reactions during sadness (P<0.05). No effect of emotion was found for wheal reactions. Hypnotic susceptibility scores were associated with increased flare reactions at baseline (r=0.56; P<0.05) and during the condition of happiness (r=0.56; P<0.05).
Our results agree with previous studies showing mood to be a predictor of cutaneous immediate-type hypersensitivity and histamine skin reactions. The results are also in concordance with earlier findings of an association between hypnotic susceptibility and increased reactivity to an allergen.
哮喘及其他超敏反应相关疾病的症状严重程度与情绪变化有关，但对于可能介导这种关系的机制知之甚少。本研究的目的是通过比较催眠诱导情绪对皮肤组胺点刺试验的风团和红斑反应的影响，来检验情绪对皮肤组胺反应性的影响。
15名高度易被催眠的志愿者在组胺点刺前及点刺后1、2、3、4、5、10和15分钟进行组胺皮肤反应性测量。这些测量在以平衡顺序呈现的三种催眠诱导情绪（悲伤、愤怒和快乐）下重复进行。皮肤反应以每分钟组胺红斑和风团面积的变化（平方毫米）来衡量。
在快乐和愤怒状态下，1至3分钟时间间隔内红斑反应的增加明显小于悲伤状态下的红斑反应（P<0.05）。未发现情绪对风团反应有影响。催眠易感性评分与基线时（r=0.56；P<0.05）和快乐状态下（r=0.56；P<0.05）红斑反应的增加相关。
我们的结果与先前的研究一致，表明情绪是皮肤速发型超敏反应和组胺皮肤反应的预测指标。这些结果也与早期关于催眠易感性与过敏原反应性增加之间关联的研究结果一致。
