Bogolepov N N, Pushkin A S
Brain Res. 1975 Aug 29;94(2):173-84. doi: 10.1016/0006-8993(75)90055-4.
Submicroscopic changes of neurons, synapses, glial cells and some elements of capillaries were established by studying chronic mirror foci which appeared in the rat cerebral cortex after implantation of cobalt-gelatinous rods into the contralateral hemisphere. The results were compared with normal control cortex and with changes after thermocoagulation of the symmetrical contralateral cortex. It is shown that epileptogenic lesions produce a significant reduction of RNA-components, edema and vacuolization of neuronal cytoplasm, hypertrophy and proliferation of glial cells. The revealed pathological changes of the synapses were manifested by dilatation of some vesicles and the appearance of heterogenic inclusions. The characteristic features of Wallerian degeneration of callosal synapses and the reversible retrograde changes of the neurons which send their axons into the traumatized zone of the contralateral hemisphere were observed to be similar after both experimental lesions.
通过研究将钴胶棒植入对侧半球后大鼠大脑皮质中出现的慢性镜下病灶，确定了神经元、突触、胶质细胞和毛细血管某些成分的亚显微变化。将结果与正常对照皮质以及对称对侧皮质热凝后的变化进行了比较。结果表明，致痫性病变导致RNA成分显著减少、神经元细胞质水肿和空泡化、胶质细胞肥大和增殖。所揭示的突触病理变化表现为一些囊泡扩张和出现异质性包涵体。在两种实验性病变后，均观察到胼胝体突触华勒氏变性的特征以及将轴突发送至对侧半球创伤区域的神经元的可逆逆行变化相似。
