Chang L W, Payan H M
Neurol Res. 1979;1(1):19-29. doi: 10.1080/01616412.1979.11739538.
Metallic cobalt and aluminum rods were implanted into the cerebral cortices of rats. Almost all the animals with cobalt implantation were found to be epileptic 30 days after the operation. Tissue samples from the cerebral cortices were sampled for electron microscopy. The most significant changes in the cobalt-implanted animals were the disintegration of the rough endoplasmic reticulum in many cortical neurons and the accumulation of neurofilaments within the perikaryon. Such filamentous accumulation was usually found near the perinuclear position, at the periphery of the neurons, and in areas where there was a paucity of regular rough endoplasmic reticulum. Large aggregates of SER-like tubulovesicular structures were also found within many neuronal processes. Some of these neuronal processes could be identified to be postsynaptic dendritic terminals. Large nuclear pseudo-inclusions consisting of cytoplasmic materials were also found in some cortical neurons. These ultrastructural changes could also be occasionally observed in the opposite (cobalt-free) hemisphere of the brain (mirror image) in the cobalt-implanted animals. However, the brains of the aluminum-implanted or blank-control animals were free from any of these changes.
将金属钴棒和铝棒植入大鼠的大脑皮层。几乎所有植入钴的动物在手术后30天被发现患有癫痫。从大脑皮层采集组织样本用于电子显微镜检查。植入钴的动物中最显著的变化是许多皮层神经元中粗面内质网的解体以及神经丝在核周体中的积累。这种丝状积累通常出现在核周位置附近、神经元周边以及粗面内质网稀少的区域。在许多神经元突起内还发现了大量类似滑面内质网的管泡状结构聚集体。其中一些神经元突起可被鉴定为突触后树突末端。在一些皮层神经元中还发现了由细胞质物质组成的大核假包涵体。这些超微结构变化在植入钴的动物大脑的对侧（无钴）半球（镜像）中偶尔也能观察到。然而，植入铝的动物或空白对照动物的大脑没有出现任何这些变化。
