Deluca A M, Chorover S L
Brain Res. 1975 Aug 29;94(2):185-97. doi: 10.1016/0006-8993(75)90056-6.
Sustained seizure activity can be induced in rabbit olfactory bulb by application of brief low-level current via chronically implanted micro-electrodes. Sensitivity to such stimulation is markedly augmented by prior surgical isolation of the ipsilateral or contralateral bulb. The isolated rabbit olfactory bulb apparently possesses an intrinsic system sufficient to acquire and retain altered neuronal excitability of an epileptiform kind. The preparation described here offers promise as a model for further studies of electrophysiological plasticity in a simple cortical system.
通过长期植入的微电极施加短暂的低强度电流，可以在兔嗅球中诱发持续性癫痫发作活动。同侧或对侧嗅球先前的手术分离会显著增强对这种刺激的敏感性。分离的兔嗅球显然拥有一个内在系统，足以获得并维持癫痫样的神经元兴奋性改变。本文所述的制备方法有望成为进一步研究简单皮质系统中电生理可塑性的模型。
