Gray C M, Freeman W J, Skinner J E
Department of Neurology, Baylor College of Medicine, Houston, TX 77030.
Exp Brain Res. 1987;68(1):210-2. doi: 10.1007/BF00255247.
A technique of cryogenic blockade was used in waking rabbits to produce complete and reversible isolation of the olfactory bulb from the rest of the brain. During cooling of the olfactory peduncle epileptiform activity occurred spontaneously in the pyriform cortex in 3 out of 20 sessions, but never in the bulb. Following removal of the cryoblockade, during the seizure state, epileptiform discharges appeared simultaneously in the bulb and pyriform cortex. In the control state, without cooling of the peduncle, epileptiform activity could be evoked in the bulb and cortex by intense electrical stimulation of either the bulb or the lateral olfactory tract. During the cryoblockade, however, intense stimulation of the bulb failed to evoke seizure-like discharges. The results demonstrate a dependency on more central olfactory structures for the induction and maintenance of epileptiform activity in the olfactory bulb.
在清醒的兔子身上采用了一种低温阻断技术，以使嗅球与大脑其他部分完全且可逆地隔离开来。在冷却嗅神经节期间，20次实验中有3次梨状皮质自发出现癫痫样活动，但嗅球从未出现过。去除低温阻断后，在癫痫发作状态下，癫痫样放电同时出现在嗅球和梨状皮质。在对照状态下，未冷却神经节时，通过强烈电刺激嗅球或外侧嗅束，可在嗅球和皮质诱发癫痫样活动。然而，在低温阻断期间，强烈刺激嗅球未能诱发癫痫样放电。结果表明，嗅球中癫痫样活动的诱导和维持依赖于更中枢性的嗅觉结构。
