肾上腺髓质素对健康人体中血管紧张素II刺激的心房利钠肽和精氨酸加压素分泌的影响。
Effects of adrenomedullin on angiotensin II stimulated atrial natriuretic peptide and arginine vasopressin secretion in healthy humans.
作者信息
Petrie M C, McDonald J E, Hillier C, Morton J J, McMurray J J
机构信息
Department of Cardiology, Western Infirmary of Glasgow, Glasgow.
出版信息
Br J Clin Pharmacol. 2001 Aug;52(2):165-8. doi: 10.1046/j.0306-5251.2001.01428.x.
AIMS
Adrenomedullin is a newly described peptide that has widespread tissue distribution. Its presence in cardiovascular (including vascular endothelial cells, smooth muscle cells, and cardiac atria and ventricles) and renal tissues, together with its vasodilatory and natriuretic properties, suggest a role in blood pressure regulation and fluid and electrolyte balance.
METHODS
Nine normal volunteers were studied to determine whether or not adrenomedullin influenced plasma atrial natriuretic peptide and arginine vasopressin concentrations during systemic angiotensin II infusion.
RESULTS
A significant (P = 0.02) augmentation of atrial natriuretic peptide concentrations, but no suppression of arginine vasopressin concentrations, was found with coinfusion of adrenomedullin and angiotensin II when compared with vehicle and angiotensin II.
CONCLUSIONS
Despite its vasodilator and natriuretic action, adrenomedullin significantly augmented angiotensin II-stimulated plasma atrial natriuretic peptide concentrations in healthy humans. This provides further evidence of a synergistic interaction between adrenomedullin and atrial natriuretic peptide and suggests that adrenomedullin may have a role in fluid and electrolyte balance and blood pressure regulation.
目的
肾上腺髓质素是一种新发现的肽，在组织中广泛分布。它存在于心血管组织（包括血管内皮细胞、平滑肌细胞以及心房和心室）和肾组织中，同时具有血管舒张和利钠特性，提示其在血压调节以及体液和电解质平衡中发挥作用。
方法
对9名正常志愿者进行研究，以确定在全身输注血管紧张素II期间，肾上腺髓质素是否会影响血浆心房利钠肽和精氨酸加压素的浓度。
结果
与单独输注血管紧张素II和溶剂相比，联合输注肾上腺髓质素和血管紧张素II时，心房利钠肽浓度显著升高（P = 0.02），但精氨酸加压素浓度未受抑制。
结论
尽管肾上腺髓质素有血管舒张和利钠作用，但在健康人体中，它能显著提高血管紧张素II刺激的血浆心房利钠肽浓度。这为肾上腺髓质素与心房利钠肽之间的协同相互作用提供了进一步证据，并提示肾上腺髓质素可能在体液和电解质平衡以及血压调节中发挥作用。
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