Didden M A, Hoekstra M P, Vollebergh J H, Schellekens A, de Jong P A
Department of Obstetrics and Gynecology, Catharina-Hospital, Eindhoven, The Netherlands.
Am J Obstet Gynecol. 1991 Sep;165(3):692-5. doi: 10.1016/0002-9378(91)90311-e.
To clarify the effects on angiotensin II and blood pressure on plasma atrial natriuretic peptide in pregnancy, angiotensin II was infused in 37 healthy, normotensive pregnant women in week 32 of gestation. Levels of atrial natriuretic peptide were determined with the women in a sitting position 3 days before the test and in the left lateral recumbent position immediately before and after the test. Levels of atrial natriuretic peptide were not influenced by parity or salt intake. They were found to be significantly higher in the left lateral recumbent position than in the sitting position. There was also a significant increase in atrial natriuretic peptide levels during angiotensin II infusion. A dose of angiotensin II less than 1.5 ng/kg/min did not affect atrial natriuretic peptide levels. Rise in atrial natriuretic peptide levels was minimally correlated with rise in mean arterial pressure, as caused by acute vasoconstriction from angiotensin II infusion. Therefore it is suggested that, in pregnancy, the response of atrial natriuretic peptide to angiotensin II is mediated not only by changes in blood pressure but also by angiotensinergic receptor activity in the atria.
为阐明孕期血浆心钠素对血管紧张素II及血压的影响，对37名妊娠32周的健康、血压正常的孕妇输注血管紧张素II。在测试前3天让这些孕妇坐位时测定心钠素水平，并在测试前及测试后立即让她们左侧卧位时测定心钠素水平。心钠素水平不受产次或盐摄入量的影响。发现左侧卧位时的心钠素水平显著高于坐位时。在输注血管紧张素II期间，心钠素水平也显著升高。血管紧张素II剂量小于1.5 ng/kg/min时不影响心钠素水平。心钠素水平的升高与血管紧张素II输注引起的急性血管收缩导致的平均动脉压升高之间的相关性极小。因此提示，在孕期，心钠素对血管紧张素II的反应不仅由血压变化介导，还由心房中的血管紧张素能受体活性介导。
