Oussoren C, Storm G
Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB, Utrecht, The Netherlands.
Adv Drug Deliv Rev. 2001 Aug 23;50(1-2):143-56. doi: 10.1016/s0169-409x(01)00154-5.
Liposomes have been proposed as carriers for the delivery of therapeutic and diagnostic agents to the lymphatic system. Subcutaneous (s.c.) injection is the route of administration most extensively studied for this purpose. Decisive factors influencing lymphatic absorption and lymph node uptake of s.c. administered liposomes are liposome size and the anatomical site of injection. Generally, other factors such as lipid composition, charge and the presence of a hydrophilic PEG-coating on the liposome surface do not substantially affect lymphatic absorption and lymph node uptake of s.c. administered liposomes. Studies on the intranodal fate of liposomes demonstrate that phagocytosis by macrophages is the most important mechanism for lymph node uptake of liposomes. The observation of relatively high uptake of liposomes in regional lymph nodes after s.c. administration has stimulated research on lymphatic targeting of liposomes for diagnostic and therapeutic applications.
脂质体已被提议作为将治疗和诊断剂递送至淋巴系统的载体。皮下注射是为此目的研究最广泛的给药途径。影响皮下注射脂质体淋巴吸收和淋巴结摄取的决定性因素是脂质体大小和注射的解剖部位。一般来说，其他因素，如脂质组成、电荷以及脂质体表面亲水性聚乙二醇涂层的存在，对皮下注射脂质体的淋巴吸收和淋巴结摄取没有实质性影响。关于脂质体在淋巴结内命运的研究表明，巨噬细胞的吞噬作用是脂质体被淋巴结摄取的最重要机制。皮下给药后区域淋巴结中脂质体摄取相对较高的观察结果激发了对脂质体用于诊断和治疗应用的淋巴靶向研究。
