Rao V L, Dogan A, Todd K G, Bowen K K, Dempsey R J
Department of Neurological Surgery, University of Wisconsin-Madison, H4/336 CSC, 600 Highland Avenue, Madison, WI 53792, USA.
Brain Res. 2001 Aug 17;911(1):96-100. doi: 10.1016/s0006-8993(01)02617-8.
This study investigated whether memantine, a non-competitive NMDA receptor antagonist is neuroprotective after traumatic brain injury (TBI) induced in adult rats with a controlled cortical impact device. TBI led to significant neuronal death in the hippocampal CA2 and CA3 regions (by 50 and 59%, respectively), by 7 days after the injury. Treatment of rats with memantine (10 and 20 mg/Kg, i.p.) immediately after the injury significantly prevented the neuronal loss in both CA2 and CA3 regions. This is the first study showing the neuroprotective potential of memantine to prevent the TBI-induced neuronal damage.
本研究调查了美金刚（一种非竞争性N-甲基-D-天冬氨酸受体拮抗剂）对成年大鼠使用可控皮质撞击装置诱导创伤性脑损伤（TBI）后是否具有神经保护作用。损伤后7天，TBI导致海马CA2和CA3区出现显著的神经元死亡（分别为50%和59%）。损伤后立即用美金刚（10和20mg/Kg，腹腔注射）治疗大鼠，可显著预防CA2和CA3区的神经元损失。这是第一项显示美金刚预防TBI诱导的神经元损伤的神经保护潜力的研究。
