Overcoming barriers with non-covalent interactions: supramolecular recognition of adamantyl cucurbit[]uril assemblies for medical applications.

Adamantane, a staple in medicinal chemistry, recently became a cornerstone of a supramolecular host-guest drug delivery system, ADA/CB[]. Owing to a good fit between the adamantane cage and the host cavity of the cucurbit[]uril macrocycle, formed strong inclusion complexes find applications in drug delivery and controlled drug release. Note that the cucurbit[]uril host is not solely a delivery vehicle of the ADA/CB[] system but rather influences the bioactivity and bioavailability of drug molecules and can tune drug properties. Namely, as host-guest interactions are capable of changing the intrinsic properties of the guest molecule, inclusion complexes can become more soluble, bioavailable and more resistant to metabolic conditions compared to individual non-complexed molecules. Such synergistic effects have implications for practical bioapplicability of this complex system and provide a new viewpoint to therapy, beyond the traditional single drug molecule approach. By achieving a balance between guest encapsulation and release, the ADA/CB[] system has also found use beyond just drug delivery, in fields like bioanalytics, sensing assays, bioimaging, Thus, chemosensing in physiological conditions, indicator displacement assays, diagnostics and hybrid nanostructures are just some recent examples of the ADA/CB[] applicability, be it for displacements purposes or as cargo vehicles.