Ericson A, Källén B A
Epidemiologic Centre, National Board of Health, Stockholm, Sweden.
Reprod Toxicol. 2001 Jul-Aug;15(4):371-5. doi: 10.1016/s0890-6238(01)00137-x.
A study was performed of congenital malformations in infants whose mothers used nonsteroidal anti-inflammatory drugs (NSAIDs) in early pregnancy. Data were obtained from an ongoing prospective recording of drug use during the first trimester. During the period July 1, 1995 through December 31, 1998, 2557 infants were born to women who reported the use of NSAIDs in early pregnancy. The OR (after consideration of maternal age, parity, and smoking habits) for any congenital malformation was 1.04 (95%CI 0.84-1.29), but the OR for cardiac defects reported to the Medical Birth Registry was 1.86 (1.32-2.62) based on 36 instances, and for orofacial clefts 2.61 (1.01-6.78) based on only six instances. By using other information sources, another four infants with cardiac defects were identified. There was no drug specificity for cardiac defects but among six mothers of infants with orofacial clefts, five had used naproxen.
一项针对母亲在孕早期使用非甾体抗炎药（NSAIDs）的婴儿先天性畸形情况的研究展开。数据取自一项正在进行的关于孕早期用药的前瞻性记录。在1995年7月1日至1998年12月31日期间，有2557名婴儿的母亲报告在孕早期使用了NSAIDs。在考虑母亲年龄、产次和吸烟习惯后，任何先天性畸形的比值比（OR）为1.04（95%可信区间0.84 - 1.29），但向医疗出生登记处报告的心脏缺陷的OR为1.86（1.32 - 2.62），基于36例病例，而口面部腭裂的OR为2.61（1.01 - 6.78），仅基于6例病例。通过使用其他信息来源，又发现了另外4例有心脏缺陷的婴儿。心脏缺陷不存在药物特异性，但在6名口面部腭裂婴儿的母亲中，有5名使用了萘普生。
