帕金森病中的运动波动和异动症

Motor fluctuations and dyskinesia in Parkinson's disease.

作者信息

Nutt J G

机构信息

Department of Neurology, School of Medicine, Oregon Health Sciences University, Portland, OR 97201-3098, USA.

出版信息

Parkinsonism Relat Disord. 2001 Oct;8(2):101-8. doi: 10.1016/s1353-8020(01)00024-4.

DOI:10.1016/s1353-8020(01)00024-4

PMID:11489675

Abstract

Motor fluctuations and dyskinesia are common complications of long-term levodopa therapy. The neural and molecular mechanisms underlying their development are partially understood. A variety of clinical strategies may reduce the unpredictability of motor fluctuations and reduce their impact. Prevention of these complications remains an elusive goal.

摘要

运动波动和异动症是长期左旋多巴治疗的常见并发症。其发生的神经和分子机制已部分明确。多种临床策略可降低运动波动的不可预测性并减轻其影响。预防这些并发症仍然是一个难以实现的目标。