Gysling E, Heisler S
Can Med Assoc J. 1975 Jul 12;113(1):32-4.
All drug effects can be explained as results of complex interactions between the drug, the patient and his condition, and additional extrinsic factors. On the basis of these three "determinants", a practical classification of untoward drug effects (UDE) is suggested. UDE lists using this classification would fulfill the physician's informational needs better than the material with which he is presently provided.
所有药物效应都可解释为药物、患者及其病情以及其他外在因素之间复杂相互作用的结果。基于这三个“决定因素”,提出了药物不良反应(UDE)的实用分类方法。使用这种分类方法列出的UDE清单比目前医生所获得的资料能更好地满足其信息需求。