Gysling E, Heisler S
Can Med Assoc J. 1975 Jul 12;113(1):32-4.
All drug effects can be explained as results of complex interactions between the drug, the patient and his condition, and additional extrinsic factors. On the basis of these three "determinants", a practical classification of untoward drug effects (UDE) is suggested. UDE lists using this classification would fulfill the physician's informational needs better than the material with which he is presently provided.