Elneil S, Skepper J N, Kidd E J, Williamson J G, Ferguson D R
Department of Pharmacology, University of Cambridge, UK.
Pharmacology. 2001;63(2):120-8. doi: 10.1159/000056122.
Adenosine 5'-triphosphate (ATP) is known to play a significant role as a neurotransmitter in smooth muscle. There is evidence to show that ATP can cause bladder contractions and may also be involved in the processing of sensory information in the urinary bladder. These effects are likely to be mediated by P2X receptors, namely P2X(1) and P2X(3), respectively. This study set out to investigate their distribution in rat and human urinary bladders. P2X(1) receptor immunoreactivity was found on detrusor muscle fibres and P2X(3) receptor immunoreactivity was found in the urothelium of both species. This is the first demonstration of a non-neuronal localisation for P2X(3) receptors. No clear evidence was found for the presence of P2X(3) receptors on calcitonin gene-related peptide-containing sensory nerves and therefore P2X(3) receptors may not have a direct role in the mediation of sensory responses to ATP in the urinary bladder.
已知5'-三磷酸腺苷（ATP）作为一种神经递质在平滑肌中发挥着重要作用。有证据表明，ATP可引起膀胱收缩，还可能参与膀胱感觉信息的处理。这些作用可能分别由P2X受体，即P2X(1)和P2X(3)介导。本研究旨在调查它们在大鼠和人类膀胱中的分布。在两种物种的逼尿肌纤维上均发现了P2X(1)受体免疫反应性，在两种物种的膀胱上皮中均发现了P2X(3)受体免疫反应性。这是首次证明P2X(3)受体的非神经元定位。未发现明确证据表明含降钙素基因相关肽的感觉神经上存在P2X(3)受体，因此P2X(3)受体可能在介导膀胱对ATP的感觉反应中没有直接作用。
