Institute of Anatomy II, Medical Faculty, Heinrich-Heine-University, Moorenstrasse 5, 40225 Düsseldorf, Germany.
Int J Mol Sci. 2020 May 12;21(10):3423. doi: 10.3390/ijms21103423.
The circadian system is an internal time-keeping system that synchronizes the behavior and physiology of an organism to the 24 h solar day. The master circadian clock, the suprachiasmatic nucleus (SCN), resides in the hypothalamus. It receives information about the environmental light/dark conditions through the eyes and orchestrates peripheral oscillators. Purinergic signaling is mediated by extracellular purines and pyrimidines that bind to purinergic receptors and regulate multiple body functions. In this review, we highlight the interaction between the circadian system and purinergic signaling to provide a better understanding of rhythmic body functions under physiological and pathological conditions.
昼夜节律系统是一种内部计时系统，它使生物体的行为和生理与 24 小时的太阳日同步。主生物钟位于下丘脑的视交叉上核（SCN）。它通过眼睛接收有关环境明暗条件的信息，并协调外周振荡器。嘌呤能信号由细胞外嘌呤和嘧啶介导，它们与嘌呤能受体结合，调节多种身体功能。在这篇综述中，我们强调了昼夜节律系统和嘌呤能信号之间的相互作用，以更好地理解生理和病理条件下有节奏的身体功能。
