Triantafillidis J K, Emmanouilidis A, Nicolakis D, Cheracakis P, Kogevinas M, Merikas E, Hereti I, Argyros N
Department of Gastroenterology, Saint Panteleimon General State Hospital, Nicea, Pireaus.
Hepatogastroenterology. 2001 Jul-Aug;48(40):1072-7.
BACKGROUND/AIMS: The aim of this prospective study was to elucidate the clinical features, indications for surgery and long-term outcome of a series of 79 Greek patients operated on for Crohn's disease.
The clinical features and follow-up of 79 out of 155 patients with definite diagnosis of Crohn's disease (51%), who were operated on at least once during the course of their disease, are analyzed. Three main locations of the disease were identified (small bowel, large bowel and small and large bowel). The need for surgery, indications for surgery and outcome of patients were analyzed and compared separately for these three main locations. The mean follow-up period after the first operation was 8.8 +/- 6.5 years.
The proportion of men to women was 1.55:1 (P = 0.068). The main indication for surgery was poor response to conservative treatment, followed by obstructive ileus, erroneous diagnosis of acute appendicitis and development of fistulae or abscesses. Statistically significant differences between the three main locations of the disease were found for obstructive ileus (P < 0.01), and bowel perforation (P < 0.0297). Enterectomy and end-to-end anastomosis was the most frequently performed operation. Minor surgical procedures were performed mainly for drainage of perianal abscess. Differences in the number of operations required (one, two and three or more) according to the three main locations of the disease were statistically significant (P < 0.044). Emergency operation was required in 17.3%. Most of the urgently operated patients had only small bowel involvement. Twenty-six percent of patients required a surgical procedure for perianal disease. One or more, major or minor, perioperative complications occurred in 13 out of 79 operated patients (16.4%). No perioperative deaths were noticed. Evolution to cancer was observed in 2% (3 patients). The outcome of patients after the operation was characterized by exacerbations and remissions. A mortality rate of 11.6% was noticed in the follow-up period. However, most deaths were unrelated to the underlying Crohn's disease.
The clinicoepidemiological characteristics of patients with Crohn's disease of Greek origin operated-on for their disease do not differ significantly from those reported from other Western or neighboring Mediterranean countries. However, other parameters such as the relatively low incidence of overall surgical need, the low incidence of colorectal cancer and the low incidence of surgery for perianal disease, all underline the importance of various genetic and environmental factors on the evolution and behavior of the disease in different parts of the world.
背景/目的：本前瞻性研究旨在阐明79例接受克罗恩病手术的希腊患者的临床特征、手术指征及长期预后。
分析155例确诊为克罗恩病患者中的79例（51%），这些患者在病程中至少接受过一次手术。确定了疾病的三个主要部位（小肠、大肠以及小肠和大肠）。分别针对这三个主要部位分析并比较了患者的手术需求、手术指征及预后。首次手术后的平均随访期为8.8±6.5年。
男女比例为1.55:1（P = 0.068）。手术的主要指征是对保守治疗反应不佳，其次是肠梗阻、急性阑尾炎误诊以及瘘管或脓肿形成。在疾病的三个主要部位之间，肠梗阻（P < 0.01）和肠穿孔（P < 0.0297）存在统计学显著差异。肠切除术和端端吻合术是最常施行的手术。小型手术主要用于肛周脓肿引流。根据疾病的三个主要部位，所需手术次数（一次、两次和三次或更多）的差异具有统计学显著性（P < 0.044）。17.3%的患者需要急诊手术。大多数急诊手术患者仅累及小肠。26%的患者因肛周疾病需要进行手术。79例手术患者中有13例（1
