Geiger H, Good R A, Day N K
Clin Nephrol. 1975;3(4):139-47.
In chronic membranoproliferative glomerulonephritis (CMPGN) the activation of the complement system through the properdin pathway plays an important role. The clearance of complement components and of the C3-proactivator (C3-PA) have been determined in 18 patients. Hemolytically active C5, C6, C7 and C3-PA were detected in the urine for the first time. The clearances of the complement components did not correlate with the clearances of other serum proteins with similar molecular weights. The specificities of the single complement components in the urine were tested by specific complement inhibitors such as hydrazine, KSCN, and the C4-inactivating factor.
在慢性膜增生性肾小球肾炎（CMPGN）中，通过备解素途径激活补体系统起着重要作用。已对18例患者的补体成分和C3前激活物（C3-PA）清除率进行了测定。首次在尿液中检测到具有溶血活性的C5、C6、C7和C3-PA。补体成分的清除率与其他分子量相似的血清蛋白清除率不相关。通过肼、硫氰酸钾和C4灭活因子等特异性补体抑制剂对尿液中单一补体成分的特异性进行了检测。
