Prasad K
Clin Pharmacol Ther. 1975 Jul;18(1):22-30. doi: 10.1002/cpt197518122.
The effects of glucagon (5, 10, and 40 mug/ml) on the amplitude and dueation of action potential, effective refractory period, dv/dt of phase 0 of action potential, membrane responsiveness, and contraction in human papillary muscles obtained from patients undergoing corrective open heart surgery were investigated. Glucagon, in none of the concentrations, produced any significant change in the amplitude and dueation of action potential, or in force of contraction. Shortening of the effective refractory period was not significant. Glucagon enhanced the conduction and the membrane responsiveness by increasing the dv/dt of phase 0 of action potential and a shift of curve to the left. It is suggested that the latter properties of glucagon would abolish the "re-entrant" type of cardiac arrhythmias produced by cardiac glycosides or other drugs that initiate and perpetuate arrhythmias dur to altered conduction.
研究了胰高血糖素（5、10和40微克/毫升）对接受心脏直视矫正手术患者的人乳头肌动作电位的幅度和持续时间、有效不应期、动作电位0期的dv/dt、膜反应性及收缩的影响。在任何浓度下，胰高血糖素均未使动作电位的幅度和持续时间或收缩力产生任何显著变化。有效不应期的缩短并不显著。胰高血糖素通过增加动作电位0期的dv/dt及使曲线左移来增强传导和膜反应性。提示胰高血糖素的后述特性可消除由强心苷或其他因传导改变而引发并持续心律失常的药物所产生的“折返”型心律失常。
