Hayashi H, Kobayashi A, Terada H, Nagao B, Nishiyama T, Kamikawa T, Yamazaki N
Jpn Heart J. 1985 Mar;26(2):289-96. doi: 10.1536/ihj.26.289.
Pantethine, which is known to be converted to coenzyme A, has been reported to have antiarrhythmic action on experimental cardiac arrhythmias. Using standard microelectrode techniques, the electrophysiological effects of pantethine under hypoxic (95% N2 + 5% CO2) perfusion were studied. Hypoxia decreased resting membrane potential, action potential amplitude and maximum velocity of phase 0 and shortened action potential duration and effective refractory period. Application of pantethine 5 X 10(-3) Gm/ml under hypoxic perfusion prolonged action potential duration and effective refractory period significantly. Prolongation of action potential duration by pantethine might be caused by an increase in intracellular ATP. The findings in this study could be an explanation of the possible antiarrhythmic effects of pantethine.
泛硫乙胺已知可转化为辅酶A，据报道其对实验性心律失常具有抗心律失常作用。运用标准微电极技术，研究了在缺氧（95% N₂ + 5% CO₂）灌注条件下泛硫乙胺的电生理效应。缺氧会降低静息膜电位、动作电位幅度和0期最大速度，并缩短动作电位时程和有效不应期。在缺氧灌注条件下应用5×10⁻³ Gm/ml的泛硫乙胺可显著延长动作电位时程和有效不应期。泛硫乙胺导致动作电位时程延长可能是由于细胞内ATP增加所致。本研究结果可能解释了泛硫乙胺可能的抗心律失常作用。
