第5天胚胎移植成功，且胚胎经航空运输进行活检和基因分析后成功妊娠。
Successful Day 5 embryo transfer and pregnancies resulting after transport of embryos by air for biopsy and genetic analysis.
作者信息
Langley M, Marek D, Cieslak J, Masciangelo C, Doody K M, Doody K J
机构信息
Center for Assisted Reproduction, Bedford, Texas 76022, USA.
出版信息
J Assist Reprod Genet. 2001 Jun;18(6):330-5. doi: 10.1023/a:1016624419635.
PURPOSE
Case studies of four in vitro fertilization (IVF) cycles where embryo transport by commercial airline followed by biopsy and genetic analysis with subsequent culture to Day 5 and resulting ongoing pregnancy.
METHOD
Retrospective clinical case study of 4 patients requiring preimplantation genetic diagnosis (PGD) testing. Normally fertilized embryos were transported in a battery-powered portable incubator by commercial airline following evaluation for fertilization under controlled conditions from the Center for Assisted Reproduction, Bedford, Texas to the Reproductive Genetic Institute, Chicago, Illinois. Following Day 3 embryo biopsy and genetic analysis, embryos were transported back to the Center for Assisted Reproduction for Day 5 embryo transfer.
RESULTS
Ongoing clinical pregnancy resulted for all patients receiving embryo transfer.
CONCLUSION
These results demonstrate the feasibility of embryo transport by air for centers that do not have the in-house capabilities to perform genetic analysis. With successful pregnancies obtained through extended culture to Day 5, embryos requiring genetic analysis can be successfully transported by air, tested, and returned to the initial facility for embryo transfer without time restriction.
目的
对四个体外受精（IVF）周期进行案例研究，这些周期中通过商业航空公司运输胚胎，随后进行活检和基因分析，接着培养至第5天并最终实现持续妊娠。
方法
对4例需要进行植入前基因诊断（PGD）检测的患者进行回顾性临床案例研究。在德克萨斯州贝德福德的辅助生殖中心，在受控条件下对正常受精的胚胎进行受精评估后，通过商业航空公司使用电池供电的便携式培养箱运输。在第3天进行胚胎活检和基因分析后，将胚胎运回辅助生殖中心进行第5天的胚胎移植。
结果
所有接受胚胎移植的患者均实现了持续临床妊娠。
结论
这些结果证明了对于没有内部基因分析能力的中心而言，通过航空运输胚胎的可行性。通过延长培养至第5天获得了成功妊娠，需要进行基因分析的胚胎可以通过航空成功运输、检测，并在无时间限制的情况下返回初始机构进行胚胎移植。
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