卵胞浆内单精子注射的成功率高于透明带下授精。连续300个治疗周期的第二批报告。

Higher success rate by intracytoplasmic sperm injection than by subzonal insemination. Report of a second series of 300 consecutive treatment cycles.

作者信息

Van Steirteghem A C, Liu J, Joris H, Nagy Z, Janssenswillen C, Tournaye H, Derde M P, Van Assche E, Devroey P

机构信息

Centre for Reproductive Medicine, Academisch Ziekenhuis VUB, Brussels, Belgium.

出版信息

Hum Reprod. 1993 Jul;8(7):1055-60. doi: 10.1093/oxfordjournals.humrep.a138191.

DOI:10.1093/oxfordjournals.humrep.a138191

PMID:8408486

Abstract

Subzonal insemination (SUZI) and intracytoplasmic sperm injection (ICSI) were carried out in 300 treatment cycles in couples unable to be helped by conventional in-vitro fertilization treatment. More oocytes were damaged by ICSI (13.5%) than by SUZI (7.1%). The normal fertilization rate was substantially higher after ICSI (51.0%) than after SUZI (14.3%) and was related to the semen characteristics. The cleavage rate was similar for both procedures (77%). After 217 embryo transfers (72.3% of the treatment cycles) 66 pregnancies were established, i.e. pregnancy rates of 22.0% per started cycle and 30.4% per embryo transfer. So far, pregnancy loss has occurred in 27.3% of the pregnancies, nine healthy children have been born after eight deliveries and 41 clinical pregnancies are progressing uneventfully. Chorionic villus sampling or amniocentesis have been performed in 35 pregnancies and 39 normal fetal karyotypes have been obtained after cytogenetic analysis.

摘要

对于无法通过常规体外受精治疗得到帮助的夫妇，在300个治疗周期中进行了卵周内授精（SUZI）和卵胞浆内单精子注射（ICSI）。与SUZI（7.1%）相比，ICSI对更多的卵母细胞造成了损伤（13.5%）。ICSI后的正常受精率（51.0%）显著高于SUZI后（14.3%），且与精液特征有关。两种操作的卵裂率相似（77%）。在217次胚胎移植后（占治疗周期的72.3%），有66例妊娠成功建立，即每个开始周期的妊娠率为22.0%，每次胚胎移植的妊娠率为30.4%。到目前为止，27.3%的妊娠发生了流产，8次分娩后有9名健康婴儿出生，41例临床妊娠进展顺利。对35例妊娠进行了绒毛取样或羊膜穿刺术，细胞遗传学分析后获得了39个正常胎儿核型。