Kaiser M G, Lamont S J
Department of Animal Science, Iowa State University, Ames 50011-3150, USA.
Poult Sci. 2001 Aug;80(8):1105-8. doi: 10.1093/ps/80.8.1105.
Early infection may result in long-term colonization of layers with Salmonella enterica sv. enteritidis (S. enteritidis, SE), resulting in shedding into table or hatching eggs. To evaluate genetic factors underlying early response to SE, genetic line differences in mortality and pathogen load at two sites (cecal lumen and spleen) were investigated. At day of hatch, chicks of four genetic lines were intra-esophageally inoculated with one of three doses of SE phage type 13a. There was a significant effect (P < 0.001) of genetic line on chick 6-d survival. The effect of genetic line was significant (P < 0.05) on survivors' SE burden in cecal content but not on SE burden per gram of spleen. The SE pathogen load of the spleen and the cecal content were not significantly correlated, indicating that independent host mechanisms are partly responsible for these two traits. Genetic line differences in chick survival and SE colonization of cecal content were demonstrated in young layer chicks.
早期感染可能导致蛋鸡长期被肠炎沙门氏菌肠炎亚种（肠炎沙门氏菌，SE）定植，从而导致病菌排入食用蛋或孵化蛋中。为了评估对SE早期反应的潜在遗传因素，研究了四个遗传品系的雏鸡在两个部位（盲肠腔和脾脏）的死亡率和病原体载量差异。在孵化当天，四个遗传品系的雏鸡经食管接种三种剂量之一的13a型SE噬菌体。遗传品系对雏鸡6日龄存活率有显著影响（P < 0.001）。遗传品系对存活雏鸡盲肠内容物中的SE负荷有显著影响（P < 0.05），但对每克脾脏中的SE负荷无显著影响。脾脏和盲肠内容物中的SE病原体载量无显著相关性，表明这两个特征部分由独立的宿主机制决定。在幼龄蛋鸡雏鸡中证实了遗传品系在雏鸡存活率和盲肠内容物SE定植方面的差异。
