Vecellio None L, Grimbert D, Becquemin M H, Boissinot E, Le Pape A, Lemarié E, Diot P
INSERM EMI-U 00-10, Groupe de Pneumologie, CHU Bretonneau, Tours, France.
J Aerosol Med. 2001 Spring;14(1):107-14. doi: 10.1089/08942680152007954.
The project for a European standard testing procedure to characterize nebulizers in terms of particle size distribution has been based on using the Andersen-Marple personal cascade impactor model 298 (A-MPCI) with a sodium fluoride reference solution. In the present study methods based on laser diffraction (Mastersizer-X) and time-of-flight (TOF)(APS) and another cascade impactor (GS1-CI) were compared with the A-MPCI. Two types of nebulizer (Pari LC+ and Microneb) were tested with all apparatuses, and a third type of nebulizer (NL9) was tested with the A-MPCI and Mastersizer-X. Nebulizers were charged with a solution of sodium fluoride in conditions reproducing the European Committee for Normalization (CEN) protocol. There was no difference between the Mastersizer-X and the A-MPCI or between the GS1-CI and the A-MPCI in terms of mass median aerodynamic diameter (MMAD). Comparison between the APS and the A-MPCI showed a significant difference with the Microneb. The geometric standard deviations (GSD) obtained with the A-MPCI were on average 10% greater than GSD obtained with the other apparatuses, but the differences were not statistically significant. We conclude that laser diffraction can be used for particle size distribution in the context of the European standard, and that the Mastersizer-X is particularly interesting for industrial practice in view of its simplicity and robustness.
旨在根据粒径分布对雾化器进行特性描述的欧洲标准测试程序项目，一直基于使用配备氟化钠参比溶液的安德森-马普尔个人级联撞击器298型（A-MPCI）。在本研究中，将基于激光衍射的方法（Mastersizer-X）、飞行时间法（TOF）（APS）以及另一种级联撞击器（GS1-CI）与A-MPCI进行了比较。使用所有仪器对两种雾化器（帕里LC+和Microneb）进行了测试，使用A-MPCI和Mastersizer-X对第三种雾化器（NL9）进行了测试。在再现欧洲标准化委员会（CEN）协议的条件下，用氟化钠溶液给雾化器充电。就质量中值空气动力学直径（MMAD）而言，Mastersizer-X与A-MPCI之间或GS1-CI与A-MPCI之间没有差异。APS与A-MPCI之间的比较显示，在Microneb方面存在显著差异。用A-MPCI获得的几何标准偏差（GSD）平均比用其他仪器获得的GSD大10%，但差异无统计学意义。我们得出结论，在欧洲标准的背景下，激光衍射可用于粒径分布的测定，鉴于其简单性和稳健性，Mastersizer-X对工业实践特别有意义。
