Effect of lincomycin on lipase formation by Staphylococcus aureus.

The production of Staphylococcus aureus lipase could be inhibited by addition of 0.1 mug/ml lincomycin to the media without affecting growth. Addition of the same amount of drug at various stages of growth inhibited further enzyme production. The enzymatic activity of the lipase could not be inhibited at a concentration of 2.5 mug/ml lincomycin.