Shibl A M
J Antimicrob Chemother. 1984 Jun;13(6):625-7. doi: 10.1093/jac/13.6.625.
The effect of subinhibitory concentrations of lincomycin on the production of lipase, coagulase and alpha-haemolysin by one lincomycin-resistant strain of Staphylococcus aureus was investigated. The highest concentration of lincomycin, which had little effect on growth, completely inhibited enzyme and haemolysin formation. The antibiotic at the concentrations used did not inactivate enzymes. Lincomycin caused no intracellular accumulation of these products, indicating a possible effect on enzyme and haemolysin synthesis. Subinhibitory concentrations of erythromycin and chloramphenicol showed no effect on enzyme and haemolysin formation.
研究了亚抑菌浓度的林可霉素对一株耐林可霉素金黄色葡萄球菌产生脂肪酶、凝固酶和α-溶血素的影响。对生长影响很小的林可霉素最高浓度，完全抑制了酶和溶血素的形成。所用浓度的抗生素并未使酶失活。林可霉素未导致这些产物在细胞内积累，表明其可能对酶和溶血素的合成有影响。亚抑菌浓度的红霉素和氯霉素对酶和溶血素的形成无影响。
