Winokur S, Nobel-Allen N L, Lucchesi B R
Eur J Pharmacol. 1975 Jun-Jul;32(02):349-56. doi: 10.1016/0014-2999(75)90303-9.
Previous in vitro studies had provided evidence to show that papillary muscles obtained from cats with chronic right ventricular failure had lost their ability to develop a positive inotropic response to glucagon. Since it is difficult to extrapolate from the isolated papillary muscle to the intact heart, studies were done to assess the effects of glucagon in the perfused isovolumically beating heart obtained from cats four months after surgical banding of the pulmonary artery for the experimental production of chronic right ventricular failure (CRVF). At the peak of the dose-response curve, glucagon increased right ventricular isovolumic pressure 25% (39.00 +/- 4.37 to 49.67 +/- 5.15 mm Hg; p less than 0.001) and right ventricular dP/dt 63% (522.2 +/- 93.9 to 852.6 +/- 159.9 mm Hg/sec; p less than 0.001) in 6 normal hearts. Similar dose related increases in right ventricular isovolumic pressure and dP/dt were obtained in 6 hearts taken from cats with chronic right ventricular failure. The respective increases in right ventricular isovolumic pressure and dP/dt were 43% (30.33 +/- 4.01 to 43.67 +/- 6.25 mm Hg; p less than 0.025) and 73% (317.50 +/- 30.29 to 550.83 +/- 89.04 mm Hg/sec; p less than 0.025). These results provide evidence that glucagon possesses the capacity to augment myocardial contractility in the heart with experimentally induced chronic right ventricular failure.
先前的体外研究已提供证据表明，从患有慢性右心室衰竭的猫身上获取的乳头肌，对胰高血糖素产生正性肌力反应的能力已经丧失。由于很难从分离的乳头肌推断到完整心脏，因此开展了研究，以评估胰高血糖素对从因实验性制造慢性右心室衰竭（CRVF）而在肺动脉进行手术结扎四个月后的猫身上获取的等容搏动灌注心脏的影响。在剂量 - 反应曲线的峰值处，胰高血糖素使6颗正常心脏的右心室等容压力增加了25%（从39.00±4.37毫米汞柱增至49.67±5.15毫米汞柱；p＜0.001），右心室dP/dt增加了63%（从522.2±93.9毫米汞柱/秒增至852.6±159.9毫米汞柱/秒；p＜0.001）。在取自患有慢性右心室衰竭的猫的6颗心脏中，也获得了右心室等容压力和dP/dt类似的剂量相关增加。右心室等容压力和dP/dt的各自增加幅度分别为43%（从30.33±4.01毫米汞柱增至43.67±6.25毫米汞柱；p＜0.025）和73%（从317.50±30.29毫米汞柱/秒增至550.83±89.04毫米汞柱/秒；p＜0.025）。这些结果提供了证据，表明胰高血糖素具有增强实验性诱导的慢性右心室衰竭心脏心肌收缩力的能力。
