Pouille F, Scanziani M
Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
Science. 2001 Aug 10;293(5532):1159-63. doi: 10.1126/science.1060342.
The temporal resolution of neuronal integration depends on the time window within which excitatory inputs summate to reach the threshold for spike generation. Here, we show that in rat hippocampal pyramidal cells this window is very narrow (less than 2 milliseconds). This narrowness results from the short delay with which disynaptic feed-forward inhibition follows monosynaptic excitation. Simultaneous somatic and dendritic recordings indicate that feed-forward inhibition is much stronger in the soma than in the dendrites, resulting in a broader integration window in the latter compartment. Thus, the subcellular partitioning of feed-forward inhibition enforces precise coincidence detection in the soma, while allowing dendrites to sum incoming activity over broader time windows.
神经元整合的时间分辨率取决于兴奋性输入总和达到产生动作电位阈值的时间窗口。在此，我们表明在大鼠海马锥体细胞中，这个窗口非常狭窄（小于2毫秒）。这种狭窄是由于双突触前馈抑制跟随单突触兴奋的延迟很短所致。同时进行的体细胞和树突记录表明，前馈抑制在体细胞中比在树突中要强得多，导致后者区域的整合窗口更宽。因此，前馈抑制的亚细胞分区在体细胞中强制进行精确的同时检测，而允许树突在更宽的时间窗口内对传入活动进行总和。
