Sanders S G, Tucker R L, Bagley R S, Gavin P R
Department of Veterinary Clinical Sciences, Washington State University, College of Veterinary Medicine, Pullman 99164-7060, USA.
Vet Radiol Ultrasound. 2001 Jul-Aug;42(4):291-6. doi: 10.1111/j.1740-8261.2001.tb00942.x.
Magnetic resonance imaging (MR) was used to make a diagnosis of equine nigropallidal encephalomalacia in a horse. Equine nigropallidal encephalomalacia is a neurodegenerative disease that has many characteristics with Parkinson-like diseases in humans. Historically, horses were euthanized based on clinical signs and exposure to the toxic weed, yellow star thistle (Centaurea solstitialis). Previously, the disease has only been confirmed on necropsy. MR imaging can provide accurate and sensitive visualization of typical lesions seen in the brain of horses affected with equine nigropallidal encephalomalacia. Lesions were seen on T1-weighted, T2-weighted and proton density images. There was no contrast enhancement following Gd-DTPA administration. Lesions seen on MR were confirmed at necropsy. Using MR to confirm a diagnosis of equine nigropallidal encephalomalacia will prevent unnecessary suffering of horses and expense to owners that would otherwise incur, while further diagnostics are performed.
利用磁共振成像（MR）对一匹马的马黑质苍白球软化症进行了诊断。马黑质苍白球软化症是一种神经退行性疾病，具有许多与人类帕金森氏症相似的特征。从历史上看，马匹是根据临床症状和接触有毒杂草黄矢车菊（Centaurea solstitialis）而被实施安乐死的。以前，该疾病仅在尸检时得到证实。MR成像能够准确、灵敏地显示受马黑质苍白球软化症影响的马匹大脑中出现的典型病变。在T1加权、T2加权和质子密度图像上均可见病变。静脉注射钆喷酸葡胺（Gd-DTPA）后无强化表现。MR所见病变在尸检时得到证实。利用MR来确诊马黑质苍白球软化症将避免马匹不必要的痛苦以及否则会给马主带来的费用，同时可进行进一步的诊断。
