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透析相关淀粉样变性

Dialysis-related amyloidosis.

作者信息

Fukuda K, Yamamoto H

机构信息

Department of Radiology, The Jikei University School of Medicine, 3--25--8 Nishi-shimbashi, Minato-ku, Tokyo, 105--8461, Japan.

出版信息

Semin Musculoskelet Radiol. 2001 Jun;5(2):113-9. doi: 10.1055/s-2001-15879.

Abstract

Dialysis-related amyloidosis (DRA) is a well-recognized complication in patients on long-term hemodialysis. It occurs secondary to the deposition of beta(2)-microglobulin, preferentially in the musculoskeletal tissues. Plain radiography demonstrates advanced DRA findings such as bone erosions and cystic lesions, but it is not suitable for the demonstration of earlier changes. Magnetic resonance imaging and ultrasound are sufficient for the detection of amyloid deposition in the periarticular soft tissues and in the evaluation of spinal complications.

摘要

透析相关淀粉样变性(DRA)是长期血液透析患者中一种广为人知的并发症。它继发于β2微球蛋白的沉积,优先沉积于肌肉骨骼组织。X线平片可显示DRA的晚期表现,如骨质侵蚀和囊性病变,但不适用于显示早期变化。磁共振成像和超声足以检测关节周围软组织中的淀粉样蛋白沉积以及评估脊柱并发症。

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