Varga J, Idelson B A, Felson D, Skinner M, Cohen A S
Arch Intern Med. 1987 Aug;147(8):1455-7.
Recent reports describe the carpal tunnel syndrome (CTS) due to amyloid infiltration of the beta 2 microglobulin protein as a frequent complication of long-term hemodialysis. Carpal synovial and cystic bone lesion amyloid deposits have been reported; however, the extent of systemic amyloid deposition has not been determined. We examined 30 patients undergoing long-term hemodialysis for CTS and performed abdominal fat tissue aspiration for amyloid staining to evaluate the presence of systemic amyloid disease. In this group, CTS was frequent (37%) and its prevalence correlated with the duration of hemodialysis. In all patients, the abdominal fat tissue, stained with Congo red, was negative for amyloid deposits. These results confirm that CTS is a frequent complication of long-term hemodialysis; however, in this study, no detectable amyloid deposits were found in abdominal subcutaneous fat tissue. Thus, abdominal fat aspiration may not be a reliable screening test for hemodialysis-associated amyloidosis.
近期报告称，β2微球蛋白蛋白的淀粉样蛋白浸润所致的腕管综合征（CTS）是长期血液透析的常见并发症。已有腕滑膜和囊性骨病变淀粉样蛋白沉积的相关报道；然而，全身淀粉样蛋白沉积的程度尚未确定。我们检查了30例因CTS接受长期血液透析的患者，并进行腹部脂肪组织抽吸以进行淀粉样蛋白染色，以评估全身淀粉样疾病的存在情况。在该组中，CTS很常见（37%），其患病率与血液透析时间相关。所有患者经刚果红染色的腹部脂肪组织均未发现淀粉样蛋白沉积。这些结果证实CTS是长期血液透析的常见并发症；然而，在本研究中，腹部皮下脂肪组织未发现可检测到的淀粉样蛋白沉积。因此，腹部脂肪抽吸可能不是血液透析相关淀粉样变性的可靠筛查试验。
