Tuomilehto J, Del Prato S
Department of Epidemiology and Health Promotion, Diabetes and Genetic Epidemiology Unit, National Public Health Institute, Mannerheimintie 166, FIN-003000 Helsinki, Finland.
Int J Clin Pract. 2001 Jul-Aug;55(6):380-3.
Glucose control remains the cornerstone of therapeutic strategies designed to reduce the risk of long-term complications in patients with type 2 diabetes. This article reviews a growing body of evidence suggesting that post-mealtime glucose spikes may exert an independent effect on diabetic complications, and discusses how a more effective strategy requires better focus on the regulation of mealtime glucose. New treatment options, specifically designed to restore a more physiological post-mealtime insulin profile, may provide better tools to ensure more comprehensive glycaemic control, which will allow for better prevention of micro- and macrovascular complications in type 2 diabetic patients.
血糖控制仍然是旨在降低2型糖尿病患者长期并发症风险的治疗策略的基石。本文综述了越来越多的证据，这些证据表明餐后血糖峰值可能对糖尿病并发症产生独立影响，并讨论了更有效的策略如何需要更好地关注餐时血糖的调节。专门设计用于恢复更符合生理的餐后胰岛素曲线的新治疗选择，可能提供更好的工具来确保更全面的血糖控制，这将有助于更好地预防2型糖尿病患者的微血管和大血管并发症。
