甲状旁腺激素未能影响灌注大鼠胰腺释放胰岛素和胰高血糖素。

Failure of parathormone to affect insulin and glucagon release from the perfused rat pancreas.

作者信息

Rebolledo O, Leclercq-Meyer V, Marchand J, Leclercq R, Malaisse W J

出版信息

Horm Metab Res. 1975 Jul;7(4):287-90. doi: 10.1055/s-0028-1093756.

Abstract

Parathormone (0.15 U/ml) failed to affect the rate of glucagon and insulin release by the perfused rat pancreas exposed to glucose in either low (3.3 mM) or high (8.3 mM) concentration. Parathormone also failed to interfere with the suppressive effect of glucose (16.6mM) upon glucagon release and its stimulatory action upon insulin secretion. Likewise, the biphasic release of both glucagon and insulin evoked by arginine (10.0 mM) in the presence of glucose (8.3 mM) was unaffected by parathormone. These findings suggest that the endocrine pancreas may not be a target organ for any direct and immediate action of parathormone.

摘要

甲状旁腺激素（0.15 U/ml）未能影响灌注的大鼠胰腺在低浓度（3.3 mM）或高浓度（8.3 mM）葡萄糖环境下胰高血糖素和胰岛素的释放速率。甲状旁腺激素也未能干扰葡萄糖（16.6 mM）对胰高血糖素释放的抑制作用及其对胰岛素分泌的刺激作用。同样，在葡萄糖（8.3 mM）存在的情况下，精氨酸（10.0 mM）引起的胰高血糖素和胰岛素的双相释放不受甲状旁腺激素的影响。这些发现表明，内分泌胰腺可能不是甲状旁腺激素任何直接和即时作用的靶器官。