Ikezawa S
Department of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.
Kurume Med J. 2001;48(2):165-70. doi: 10.2739/kurumemedj.48.165.
We examined the prevalence of Chlamydia pneumoniae in acute respiratory tract infection and association of C. pneumoniae infection and reactive airway disease in Japanese children. Four hundred eleven children with acute respiratory tract infection were enrolled in this study, and C. pneumoniae was isolated from 58 (14.1%) patients by culture. Evidence of infection with C. pneumoniae was detected in 58 children with pneumonia (34.5%), bronchitis (41.4%) and upper respiratory tract infection (24.1%). Twenty-nine (50.0%) out of 58 patients were younger than 5 years old and 18 (31.0%) had wheezing at first visit. A logistic test for anti-C. pneumoniae-specific IgE showed the deference in the fluorescence unit between the patients with C. pneumoniae infection with and without wheezing was statistically significant (Po = 0.02748, to = 2.31891). In conclusion, C. pneumoniae seems to be an important respiratory tract pathogen among young Japanese children, and our results support the association of C. pneumoniae infection and reactive airway disease.
我们研究了日本儿童急性呼吸道感染中肺炎衣原体的患病率以及肺炎衣原体感染与反应性气道疾病的关联。本研究纳入了411名急性呼吸道感染儿童，通过培养从58名（14.1%）患者中分离出肺炎衣原体。在58名患有肺炎（34.5%）、支气管炎（41.4%）和上呼吸道感染（24.1%）的儿童中检测到肺炎衣原体感染的证据。58名患者中有29名（50.0%）年龄小于5岁，18名（31.0%）初诊时有喘息症状。针对肺炎衣原体特异性IgE的逻辑检验显示，有喘息和无喘息的肺炎衣原体感染患者之间荧光单位的差异具有统计学意义（P0 = 0.02748，t0 = 2.31891）。总之，肺炎衣原体似乎是日本幼儿重要的呼吸道病原体，我们的结果支持肺炎衣原体感染与反应性气道疾病之间的关联。
