Emre U, Sokolovskaya N, Roblin P M, Schachter J, Hammerschlag M R
Department of Pediatrics, State University of New York Health Science Center at Brooklyn 11203, USA.
J Infect Dis. 1995 Jul;172(1):265-7. doi: 10.1093/infdis/172.1.265.
An association of Chlamydia pneumoniae infection and reactive airway disease has been demonstrated in children. To determine if C. pneumoniae infection triggers production of C. pneumoniae-specific IgE, sera were examined from 45 children with and without C. pneumoniae infection. Anti-C. pneumoniae IgE was demonstrated by immunoblotting in 12 (85.7%) of 14 culture-positive asthmatic patients with wheezing compared with only 1 (9.1%) of 11 culture-positive patients with pneumonia, 2 (18.2%) of 11 culture-negative asthmatic children with wheezing, and 2 (22.2%) of 9 culture-negative asymptomatic patients. The most commonly recognized proteins were at 98 (82.4%), 78 (58.8%), 58-60 (70.6%), and 36 kDa (64.7%). The presence of anti-C. pneumoniae IgE by immunoblotting was not associated with the presence of anti-C. pneumoniae IgG and IgM by microimmunofluorescence. These results suggest that production of specific IgE may be an underlying mechanism leading to reactive airway disease in some patients with C. pneumoniae infection.
肺炎衣原体感染与反应性气道疾病之间的关联已在儿童中得到证实。为了确定肺炎衣原体感染是否会触发肺炎衣原体特异性IgE的产生，研究人员检测了45名有或无肺炎衣原体感染的儿童的血清。通过免疫印迹法在14名培养阳性且伴有喘息的哮喘患者中有12名（85.7%）检测到抗肺炎衣原体IgE，相比之下，11名培养阳性的肺炎患者中只有1名（9.1%）、11名培养阴性且伴有喘息的哮喘儿童中有2名（18.2%）、9名培养阴性的无症状患者中有2名（22.2%）检测到该抗体。最常识别的蛋白分子量分别为98 kDa（82.4%）、78 kDa（58.8%）、58 - 60 kDa（70.6%）和36 kDa（64.7%）。通过免疫印迹法检测到的抗肺炎衣原体IgE的存在与通过微量免疫荧光法检测到的抗肺炎衣原体IgG和IgM的存在无关。这些结果表明特定IgE的产生可能是导致一些肺炎衣原体感染患者出现反应性气道疾病的潜在机制。
