Syme R, Glück S
Department of Oncology, Faculty of Medicine, University of Calgary, Tom Baker Cancer Centre, AB, Canada.
Transfus Apher Sci. 2001 Apr;24(2):117-24. doi: 10.1016/s1473-0502(01)00005-2.
Over the last decade there has been great interest in generating populations of antigen presenting cells (APC), which can be exploited to improve immune responses to a variety of diseases including malignancies. Dendritic cells (DC) are an APC population that are easily generated ex vivo using a variety of cytokines. Cytokines can also be used to further manipulate these cells in maturation and function. The following discussion will provide an overview of dendritic cell isolation and generation with a focus on the role cytokines play in this process.
在过去十年中，人们对生成抗原呈递细胞（APC）群体产生了浓厚兴趣，这些细胞可用于改善对包括恶性肿瘤在内的多种疾病的免疫反应。树突状细胞（DC）是一种APC群体，使用多种细胞因子可在体外轻松生成。细胞因子还可用于进一步调控这些细胞的成熟和功能。以下讨论将概述树突状细胞的分离和生成，重点关注细胞因子在此过程中所起的作用。
