Weiss A P, Heckers S
Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA.
Scand J Psychol. 2001 Jul;42(3):239-50. doi: 10.1111/1467-9450.00234.
The past three decades have seen tremendous growth in our understanding of the cerebral underpinnings of schizophrenia. including the neural correlates of the cognitive impairment seen in this syndrome. In this article we review the role that structural and functional neuroimaging has played in elucidating the cerebral basis for the declarative memory deficits associated with schizophrenia. Memory impairment in schizophrenia appears to involve abnormal connectivity between the prefrontal cortex and three regions important in normal learning and memory: the hippocampus, thalamus, and cerebellum.
在过去三十年里，我们对精神分裂症的大脑基础，包括该综合征中认知障碍的神经关联，有了极大的认识进展。在本文中，我们回顾了结构和功能神经影像学在阐明精神分裂症相关陈述性记忆缺陷的大脑基础方面所起的作用。精神分裂症中的记忆障碍似乎涉及前额叶皮质与在正常学习和记忆中起重要作用的三个区域（海马体、丘脑和小脑）之间的异常连接。
