小鼠缝隙连接基因连接蛋白29在坐骨神经中高度表达，并在大脑发育过程中受到调控。
The mouse gap junction gene connexin29 is highly expressed in sciatic nerve and regulated during brain development.
作者信息
Söhl G, Eiberger J, Jung Y T, Kozak C A, Willecke K
机构信息
Institut für Genetik, Abteilung Molekulargenetik, Universität Bonn, Germany.
出版信息
Biol Chem. 2001 Jun;382(6):973-8. doi: 10.1515/BC.2001.122.
A novel mouse gap junction gene, coding for a presumptive protein of 258 amino acids (molecular mass: 28 981 Da), has been designated connexin29. This single copy gene was mapped to distal mouse chromosome 5 and shows 75% sequence identity to a human connexin30.2 sequence in the database. Connexin29 mRNA (4.4 kb) is highly expressed in mouse sciatic nerve and less abundant in spinal cord as well as in adult brain, where it increased 12-fold between day 7 and 14 post partum. Our expression data suggest that the new connexin gene is active in myelin-forming glial cells.
一个新的小鼠间隙连接基因，编码一种推测由258个氨基酸组成的蛋白质（分子量：28981道尔顿），已被命名为连接蛋白29。这个单拷贝基因被定位到小鼠5号染色体远端，与数据库中人类连接蛋白30.2序列具有75%的序列同一性。连接蛋白29信使核糖核酸（4.4千碱基）在小鼠坐骨神经中高度表达，在脊髓和成年大脑中表达较少，在产后第7天到第14天期间其表达量增加了12倍。我们的表达数据表明，这个新的连接蛋白基因在形成髓鞘的神经胶质细胞中具有活性。
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