Lutz D, Haist B, Stacher A
Int J Clin Pharmacol Biopharm. 1975 Apr;11(3):226-31.
The effect of adriamycin on PHA-stimulated lymphocytes is dose-dependent. An adriamycin concentration of 0.2 mug/ml reduces blast transformation and RNA synthesis as well as cell proliferation (DNA-synthesis). The lower concnetration of 0,01 mug/ml, which can be found inpatients for several hours after i.v. application, results only in a transitional inhibition of uridine nucleolar labelling. This inhibition of uridine nucleolar labelling appears more rapidly after adriamycin addition than that of thymidine labelling. Lymphocytes preincubated with adriamycin are effected similarly to lymphocyte cultured in the continuous presence of adriamycin.
阿霉素对PHA刺激的淋巴细胞的作用是剂量依赖性的。阿霉素浓度为0.2微克/毫升时可降低母细胞转化、RNA合成以及细胞增殖（DNA合成）。静脉注射后数小时内在患者体内可发现的较低浓度0.01微克/毫升，仅导致尿苷核仁标记的短暂抑制。添加阿霉素后，尿苷核仁标记的这种抑制比胸苷标记的抑制出现得更快。预先用阿霉素孵育的淋巴细胞与在持续存在阿霉素的情况下培养的淋巴细胞受到的影响相似。
