Greiner R, Skaleric K, Ehrengruber H
Radiologe. 1979 Jul;19(7):254-61.
Survey of 289 patients with squamous cell carcinoma of the esophagus treated solely by irradiation between 1961 and 1973. All patients fit for radiotherapy -- uniformly without further selection -- received a local dose of at least 6500 rads. This resulted in a 18% one year survival rate; only one patient lived more than five years. All patients were compared using different criteria to correlate the initial findings at the time of diagnosis with the type of therapy and the prognosis. Three treatment plans were established according to the initial clinical findings: a) palliative therapy, b) locally curative therapy and c) radical curative therapy. The treatment plan which seems to show the best results consists of preoperative irradiation with adjuvant chemotherapy followed by surgical removal of the tumor. This plan should be pursued in all appropriate patients.
对1961年至1973年间仅接受放射治疗的289例食管鳞状细胞癌患者进行的调查。所有适合放疗的患者——未经进一步筛选——均接受了至少6500拉德的局部剂量照射。这导致一年生存率为18%；只有一名患者存活超过五年。使用不同标准对所有患者进行比较，以将诊断时的初始发现与治疗类型和预后相关联。根据初始临床发现制定了三种治疗方案：a）姑息治疗，b）局部治愈性治疗和c）根治性治疗。似乎显示出最佳效果的治疗方案包括术前放疗加辅助化疗，然后手术切除肿瘤。所有合适的患者都应采用该方案。
